南华大学公共卫生学院杨胜园教授简介

一、基本情况

杨胜园，女，博士，教授，博士研究生导师，湖南省卫生健康高层次人才，全国卫生化学教育学组委员会副主任委员，中华预防医学会卫生检验专业委员会常务委员，湖南省卫生检验专业委员会委员，湖南省检验检测学会理事，美国佛罗里达大学访问学者。从事专业为卫生检验与检疫专业(理化方向)，主讲“卫生化学”、“空气理化检验”等课程，主要从事卫生检验新方法新技术研究。先后主持国家自然科学基金3项、湖南省自然科学基金3项及其他项目多项。获湖南省自然科学成果奖二等奖1项，湖南省教学成果三等奖1项。主编、参编全国规划教材《空气理化检验》、《卫生化学》等10余部。发表科研论文100余篇。

二、教学与科研情况

1. 科研成果

湖南省自然科学奖二等奖，光敏材料化学生物传感方法及健康相关因子检测研究，排名第一，2021年

2. 近年主持的科研项目

1) 国家自然基金面上项目：功能化HOFs@水凝胶介导的放射性核素铀的高效吸附和灵敏检测研究（82473686）2025.1-2028.12 主持

2) 湖南省自然基金面上项目：咪唑基功能化-过渡金属后修饰HOFs检测放射性核素铀的研究（2025JJ50657）2025-2027 主持

3) 湖南省卫生健康委重大科研专项：多靶标放射性核素同步检测的均相电化学传感新方法研究（R2023036）2025.1-2027.12，主持

4) 国家自然基金面上项目： 基于DNA水凝胶的微滴液晶生物传感检测体系的研究与应用（82073604），202101-202412 主持

5) 铀矿冶放射性控制技术湖南省工程研究中心、湖南省铀尾矿库退役治理技术工程技术研究中心联合开放课题: 铀的液晶生物传感检测新方法研究（2019YKZX2005）2020.1-2021.12 主持

6) 国家自然基金青年基金：催化信标液晶生物传感检测铀的方法学研究(11205085)，201301-201512 主持

7) 湖南省自然基金面上项目，精准检测铀的液-液型液晶生物传感研究（2018JJ2323），201901-202112，主持

8) 湖南省自然基金青年基金：小分子抗原的非标记液晶免疫传感检测方法研究（14JJ3101），201501-201712 主持

9) 湖南省教育厅优秀青年项目：基于液晶-水界面分子取向变化的重金属离子液晶生物传感方法研究（15B202），201601-201712 主持

10) 国家重点实验室开放基金：高灵敏液晶生物传感检测铀的方法学研究（2012018），2012-2015 主持

3. 近五年代表性论文

(1) Liu Yu, Liu Chunlin, Deng Qiuhui, YuYao, Tang Xian, Le Li,*, Craig A. Grimesc, Yang Shengyuan*, Cai Qingyun, Zhen Deshuai*, A β-keto-enamine covalent organic framework fluorescent switch for selective and sensitive UO₂²⁺ detection. Sensors & Actuators: B. Chemical, 2025, 433: 137564.

(2) Zhang Xu, Dong Yaolin, Lia Wanwan, Xiao Fubing, Wu Zhaoyang, Yang Shengyuan*, A label-free liquid crystal-based immunosensor for the detection of indole-3-acetic acid, Liquid Crystals, 2025

(3) Hu Congcong, Liu Can, Zhang Xu, Tong Wei, Yin Yu, Liu Jinquan, Yang Shengyuan*，“Silver effect” enhanced fluorescence for sensitive detection of crystal violet utilizing long wavelength emission bimetallic gold-silver nanoclusters. Microchemical Journal，2024, 205: 111304.

(4) Zhen Deshuai, Liu Chunlin, Deng Qiuhui, Li Le*, Craig A. Grimes, Yang Shengyuan*, Cai Qingyun, Liu Yu*, Novel Olefin-Linked Covalent Organic Framework with Multifunctional Group Modification for the Fluorescence/ Smartphone Detection of Uranyl Ion, ACS Appl. Mater. Interfaces, 2024,16: 27804-27812.

(5) Wang Wenjuan, Chen Danrong, Cai Yujiao, Liu Zijing, Yang Hongfen, Xie Hongbin, Liu Jinquan, Yang Shengyuan*, Sodium alginate hydrogelation mediated paper based POCT sensor for visual distance reading and smartphone-assisted colorimetric dual-signal determination of L-lactate, Anal. Methods, 2024, 16: 2077-2084.

(6) Liu Bin, Yin Yu, Li Qianwen, Li Wanwan, Xiao Fubing, Liu Jinquan, Tan Yan*, Yang Shengyuan*, Dual-signal detection of tannic acid in red wines based on the peroxidase activity of carbon dots, Anal. Methods,2024, 16,2948-2958.

(7) Liu Jinquan, Shi Jiao, Zhong Miao, Wang Yating, Zhang Xinxin, Wang Wenyu, Chen Zhijun, Tan Yan, Xu Dongyun, Yang Shengyuan*, Li Le*, A novel electrochemical sensing method based on an amino-functionalized MXene for the rapid and selective detection of Hg²⁺, Anal. Methods, 2024, 16: 244-252.

(8) Li Qianwen, Yin Yu, Wang Wenjuan, Liu Bin, Tong Wei, Zhang Xu, Liu Jinquan*, Yang Shengyuan*, A Dual-Signal Sensing for the Visual and Luminescent Detection of p-Phenylenediamine Based on Cerium-Nitrogen-Co-Doped Carbon Dots, Journal of Fluorescence, 2024, 39(10): e4912

(9) Hu Congcong, Yin Yu, Huang Chongyang, Dong Yaolin, Liu Jinquan, Xiao Fubing, Yang Shengyuan*, Cobalt-nitrogen co-doped carbon dots for the colorimetric and fluorometric dual-mode detection of gallic acid, Microchemical Journal, 2024, 197: 109735.

（10）Yu Yin, Xiwen Wu, Chongyang Huang, Yaolin Dong, Jinquan Liu, Yan Tan, Hao Liang, Shengyuan Yang*，Microwave synthesized novel biomass carbon dots applied in the fluorescent detection of crystal violet，Luminescence，2024，39（5）：e4778

(11) Fan Pengfei, Liu Can, Li Qianji, Hu Congcong, Wu Xiwen, Zhang Xiaohuan, Liang Hao*, Yang Shengyuan*, Microwave-assisted rapid synthesis of ovalbumin-stabilized gold nanoclusters for picric acid determination, J. Cent. South Univ., 2023, 30: 74-84.

(12) Li Feifei, Hu Congcong, Su Wenen, Liang Hao, Xiao Fubing, Liu Jinquan, Tan Yan, Yang Shengyuan*. A self-cascade system based on Ag nanoparticle/single-walled carbon nanotube nanocomposites as an enzyme mimic for ultrasensitive detection of l-cysteine[J]. Analytical methods, 2023,15(26):3251-3258

(13) Qianji Li, Xiwen Wu, Xiaohuan Zhang, Wenen Su, Yan Tan, Pengfei Fan, Jinquan Liu*, Shengyuan Yang*, Green and rapid synthesis of biomass carbon dot-based fluorescence sensing for the sensitive determination of oxytetracycline, Anal. Methods, 2023,15,1569

(14) Pengfei Fan, Can Liu, Congcong Hu, Feifei Li, Xi Lin, Shengyuan Yang*, Fubing Xiao*. Green and facile synthesis of biomass iron-doped carbon dots as dual-signal colorimetric and fluorometric probe for the detection of ascorbic acid. New Journal of Chemistry, 2022,46, 2526-2533.

(15) Zhong Miao^#, Yang Shengyuan^#, Chen Lei, Liu Chen, Shi Jiao, Liang Hao, Xiao Xilin, Li Le, Liu Jinquan*. Highly sensitive and efficient fluorescent sensing for Hg²⁺ detection based on triple-helix molecular switch and exonuclease III-assisted amplification.  Analytica Chimica Acta, 2022,1205: 339751. (IF：6.911 )

(16) Fubing Xiao, Hong Li, Peng Xie, Jie Liu, Wenfang Du*, Le Li, Shengyuan Yang*, Zhaoyang Wu. Colloidal templating of highly ordered porous amidoxime- functionalized hydrogel for intelligent treatment of uranium contaminated water, Chemical Engineering Journal, 2022, 431: 134141 (IF：16.744 ).

(17) Pengfei Fan, Can Liu, Congcong Hu, Feifei Li, Xi Lin, Fubing Xiao, Hao Liang, Le Li，Shengyuan Yang*. Orange-emissive N,S-co-doped carbon dots for label-free and sensitive fluorescence assay of vitamin B₁₂，New Journal of Chemistry, 2022, 46(2): 877-882.

(18) Feifei Li, Pengfei Fan, Xinbei Chen, Xi Lin, Can Liu, Congcong Hu, Shengyuan Yang*, Fubing Xiao*.  A ratiometric fluorescence strategy based on copper nanoclusters/carbon dots for sensitive detection of doxorubicin. Luminescence, 2022, 37 (6) :868-875.

(19) Xuezhi Tong, Hao Zhang, Xiang Fan, Shengyuan Yang *, Dongyang Chen*, JiaLi Feng, Shan Tan，Dong Zeng. Rapid determination of 14 odorous compounds in drinking water using gas chromatography-mass spectrometry coupled with headspace solid-phase microextraction pretreatment. Analytical Methods, 2022, 14, 5076-5080.

(20) Pengfei Fan^⊥, Shunzhen He^⊥, Jianlin Cheng, Congcong Hu, Can Liu, Shengyuan Yang*, Jinquan Liu*. L-cysteine modified silver nanoparticles-based colorimetric sensing for the sensitive determination of Hg²⁺ in aqueous solutions. Luminescence, 2021,36(3):698-704.

(21) Linlin Yan, Xiao Ge Qiang Xiong, Fei Chen*, Jing Liang, Zhen Zhang, Shengyuan Yang*, Uncertainty evaluation for determination of ¹⁴C in urine samples by wet oxidation method. Radiation Medicine and Protection, 2021, 2(4): 171-175(卓越期刊).

(22) Congcong Hu, Ping Li, Zhaoyang Wu, Fengfei Fan, Duo Qian, Yuxin Yi, Shengyuan Yang*, Fubing Xiao*. A novel liquid crystal sensing platform for highly selective UO₂²⁺ detection based on UO₂²⁺-specific DNAzyme. Analytical Methods, 2021, 13 (40)：4732-4738.

(23) Xi Lin, Dongliang Xuan, Feifei Li, Can Liu, Pengfei Fan, Fubin Xiao, Hao Liang, Shengyuan Yang*. DNA-AgNCs as a fluorescence turn-off probe for dual functional detection of H₂O₂ and Fe(II) ions. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 229: 117894.

(24) Xi Lin^#, Shunzhen He^#, Dongliang Xuan, Hao Liang, Fubing Xiao, Feifei Li, Can Liu, Pengfei Fan, Congcong Hu, Shengyuan Yang*. A pH-Dependent Colorimetric Probe Based on Sodium Dodecyl Sulfate Silver Nanoparticles for Cadmium(II) and Aluminum(III) Determination. ChemistrySelect, 2020, 5(13): 4118- 4123.

(25) Xi Lin, Dongliang Xuan, Hao Liang, Fubing Xiao, Feifei Li, Can Liu, Pengfei Fan, Congcong Hu, Shengyuan Yang*, Yong Liu*. Colorimetric detection uranyl ions based on the enhanced peroxidase-like activity by GO adsorption. Journal of Environmental Radioactivity, 2020, 220-221(9): 106299.

(26) Feifei Li, Yajie Yu, Fubing Xiao, Hao Liang, Can Liu, Pengfei Fan, Shengyuan Yang*. Colorimetric strategy for ascorbic acid detection based on the oxidase‐like activity of silver nanoparticle single-walled carbon nanotube composites. Luminescence, 2020, 35:1084-1091

4. 专利

(1) 杨胜园, 林茜, 陆一松, 肖锡林, 李菲菲, 刘璨. 一种银纳米簇荧光探针和铀酰离子的检测方法, 专利号：ZL201811062403.3

(2) 杨胜园，何顺珍，陆一松，林茜，李菲菲. 一种检测水中痕量金属离子的方法，专利号：2018109232.X

5. 教改课题

1) 湖南省学位与研究生教育改革研究项目. “双一流”背景下卫生检验专业研究生教学改革模式研究与实践. 2020/01-2021/12.主持

2) 湖南省普通高等学校教育改革研究项目.《医学技术类教学质量国家标准》指导下的卫生检验与检疫专业教学质量保障体系的构建. 2020/01-2021/12 主持

6. 专著和教材

1) 主编《空气理化检验》杨胜园主编，北京：人民卫生出版社，第3版，2025年。

2) 副主编《卫生化学》康维钧主编，北京：人民卫生出版社，第9版，2025年。

3) 参编专著《现代卫生化学》康维钧主编，北京：人民卫生出版社，第2版，2021年。

4) 参编《卫生化学》康维钧主编，北京：人民卫生出版社，第8版，2017年。

5) 参编《空气理化检验》吕昌银主编，北京：人民卫生出版社，第2版，2014年。

6) 参编《卫生检验实验教程》王永生主编，北京：人民卫生出版社，第1版，2011年。

三、人才培养

主讲本科课程：空气理化检验、卫生化学

主讲研究生课程：现代卫生理化检验

四、联系方式：

电 话：0734-8281541（办）

E-mail：yangshyhy@126.com