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公共卫生学院
博士生导师简介-李乐
2022-11-07 10:50  

 

名:

李乐

位:

博士

工作单位:

南华大学研究生院

职称/职务:

教授/院长

贯:

湖南娄底

研究方向:

卫生检验学/放射生物学

一、基本情况

  教授,博士生导师,湖南省芙蓉学者(青年),湖南省青年骨干教师典型环境污染与健康危害湖南省重点实验室常务副主任。兼任中国毒理学会放射毒理专委会委员、中国环境诱变剂学会辐射与健康专委会委员、中华预防医学会放射卫生专委会青委常务委员、全国高等学校卫生检验与检疫专业教材评审委员会委员、湖南省检验检测学会副会长、湖南省预防医学会卫生检验专业委员会常务委员等学术任职。主要从事环境有毒有害物质检测新方法新技术、放射污染防控与生物修复、辐射生物效应等研发工作。

       近年来,主持国家自然科学基金、省部级项目9项,作为核心成员参与国家自然基金重点项目、国防重大基础研究项目、国家自然科学基金重大研究计划培育项目、国家核能开发项目等重大科研项目7项,发表科研论文80余篇,申报国家发明专利21获湖南省教学成果二等奖1主编专著1部,副主编教材1部。

二、教学与科研情况

1.主要项目

1

国家自然科学基金:基于痕量铀精准识别的超分子自组装稀土功能化纳米比率荧光传感体系构建及应用2022-2025,主持

2

国家自然科学基金:基于铀多元配位的磁性生物吸附剂构建及选择性吸附铀酰离子机理,2015-2017,主持

3

湖南省重点研发计划:铀尾矿库放射性废水深度净化与监测技术研究,2018-2020年,主持

4

国防基础科研重点项目,××××××净化技术研究,2012-2015主持子课题

5

国家自然科学基金重点项目,铀矿酸法地浸退役采区地下水污染物迁移转化机理研究2020-2023核心成员

6

国家自然科学基金重点项目,粤北铀尾矿库及周边地区放射性污染产生机制及控制原理,2014-2018,核心成员

7

国家自然科学基金重大研究计划培育项目,选择性吸附海水铀的纳米生物吸附剂的制备及性能研究,2014-2017,核心成员

8

国家自然科学基金:耐辐射气奇球菌PPrM基因靶RNA/靶蛋白筛选及其抗辐射调控网络研究,2013-2016,参与

9

国家自然科学基金:PLK1介导4E-BP1磷酸化在放射损伤细胞G2/M期检查点的调节功能机制研究,2013-2016,参与

10)

国家自然科学基金:酸法地浸采铀矿山退役采区地下水沉积物中微生物介导下植酸水解与磷酸盐-U(VI)生物矿化的耦合作用研究,2018-2021,参与

11)

国家自然科学基金:沙眼衣原体感染依赖性免疫优势抗原的筛选及保护性初步评价,2013-2015,参与

12

国家自然科学基金:催化信标液晶生物传感检测铀的方法学研究,2013-2015,参与

13

国家自然科学基金:满江红和满江红鱼腥藻组成的植物-微生物共生体系去除水中铀的机理,2014-2016,参与

14

湖南省自然科学基金:亲铀磁性生物吸附剂制备及其吸附铀的行为与机理,2017-2019,主持

15

湖南省教育厅优秀青年基金:新型生物功能吸附剂构建及提铀行为与机理,2017-2018,主持

16

湖南省重点研发计划子课题:构建功能植物群落高效修复铀和镉污染土壤的强化技术,2016-2019,主持

2.成果、奖项

1)成果

1

《基于核医结合的公共卫生人才培养模式及保障体系的研究与实践》。获湖南省教学成果奖二等奖,第四,2016年。

2)

国家发明专利:一种检测铀酰离子的纳米金-DNA网状结构电化学生物传感器及其制备方法和应用。ZL201910962479.X。第一,2022

3)

国家发明专利:一种杯芳烃修饰的人磁性纳米吸附剂制备及吸附低浓度铀的方法。ZL201710396529.3。第一,2019年。

4)

国家发明专利:一种偕胺肟修饰的磁性纳米生物吸附剂制备及其吸附低浓度铀的方法。ZL201710962737.5。第一,2019年。

5

国家发明专利:用于含铀废水中铀的吸附剂与含铀废水的吸附方法。

ZL201810813724.6。第一,2018年。

6

国家发明专利一种复合水凝胶的制备方法、复合水凝胶及其应用202011609532.7第一,2020年。

7

国家发明专利一种疫苗接种后现场留观系统CN202111276500.4第一,2021年。

8

国家发明专利一种移动疫苗接种车的疫情防控管理系统CN202111290311.2第二,2022年。

9

国家发明专利:一种功能化微生物吸附剂制备及吸附低浓度铀的方法。ZL2014102348349。第四,2014年。

10

国家发明专利:一种评价植物修复放射性核素污染土壤潜力的新方法。ZL201510171334X。第四,2015年。

11)

国家发明专利:利用斑马鱼胚胎Frizzled基因的相对表达量评价低剂量伽马射线辐照损伤的方法。ZL201910484244.4。第五,2019年。

 

2主要科研论文

1) Lin Sun, Lei Chen, Bingyu Zhu, Mi Gong, Hong Chen, Ziwei Tang, Xiayu Zhou, Jinquan Liu, Deshuai Zhen, Le Li*.An ultra-sensitive strategy for fluorescent detection of uranyl ions based on MoS2 nanosheet and entropy-driven amplification. Microchemical Journal, 2022, doi.org/10.1016/j.microc.2022.108050

2) Lin Sun, Jinquan Liu, Deshuai Zhen, Zhongran Dai, Shuangyang Tang, Bingyu Zhu, Lei Chen, Hong Chen, Mi Gong, Ziwei Tang, Yu Hu, Le Li*. Advances of biosensors for UO22+ detecting based on specific DNAzyme. Inorganic Chemistry Communications. 2022,138:109234

3) Bingyu Zhu, Le Li*, Zhongran Dai, Shuangyang Tang, Deshuai Zhen, Lin Sun, Lei Chen, Chen Tuo, Ziwei Tang. Synthesis of amidoximated polyacrylonitrile/sodium alginate composite hydrogel beed and its use in selective and recyclable removal of U(VI). Journal of Radioanalytical and Nuclear Chemistry.2022,331(4):1669-1682

4) Zhongran Dai,Junjie Lian, Yusu Sun, Le Li. Hui Zhang,Nan Hu, Dexin Ding, Fabrication of g-C3N4/Sn3O4/Ni electrode for highly efficient photoelectrocatalytic reduction of U(VI), Chemical Engineering Journal, 2022, 433(3): 133766.

5) Fubing Xiao, Hong Li, Peng Xie, Jie Liu, Wenfang Du, Le Li, Shengyuan Yang, Zhaoyang Wu. Colloidal templating of highly ordered porous amidoxime-functionalized hydrogel for intelligent treatment of uranium contaminated water, Chemical Engineering Journal, 2022, 431: 134141.

6) Zhongran Dai, Shang Zhao, Junjie Lian, Le Li, Dexin Ding . Efficient visible-light-driven photoreduction of U(VI) by carbon dots modified porous g-C3N4, Separation and Purification Technology,2022,doi.org/10.1016/j.seppur.2022.121590

7) Lei Chen, Jinquan Liu, Chen Cao, Shuangyang Tang, Changyin Lv, Xilin Xiao, Shengyuan Yang, Ling Liu, Lin Sun, Bingyu Zhu, Le Li*. A dual-signal amplification electrochemical sensing for the sensitive detection of uranyl ion based on gold nanoparticles and hybridization chain reaction. Analytica Chimica Acta.2021, 1184: 338986

8) Chen Cao,Jinquan Liu,Shuangyang Tang, Zhongran Dai,Fubing Xiao,Weiqing Rang,Ling Liu,Tuo Chen,Yali Yuan,Le Li*. Amplified electrochemical determination  of UO22+ based on the cleavage of the DNAzyme and DNA-modified gold nanoparticle network structure[J].Microchimica Acta,2020,doi.org/10.1007/s00604-020-04263-1

9) Wei Lu,Zhonagran Dai,Le Li*,Jinquan Liu,Shengping Wang, Huixian Yang,Chen Cao,Ling Liu,Tuo Chen,Bingyu Zhu,Lin Sun,Lei Chen,Huiqin Li,Peng Zhang.Preparation of composite hydrogel (PCG) and its adsorption performance for uranium(VI)[J].Journal of Molecular Liquids,2020,303.

10) Zhongran Dai, Yusu Sun, Hui Zhang, Dexin Ding ,Le Li. Photocatalytic reduction of U(VI) in wastewater by mGO/g-C3N4 nanocomposite under visible LED light irradiation, Chemosphere, 2020, 254: 126671.

11) Dongfeng Yang,Yanling Liu,Shan Liu, Chun Li,Yang Zhao,Le Li, Shaoyou Lu. Exposure to heavy metals and its association with DNA oxidative damage in municipal waste incinerator workers in Shenzhen, China[J]. Chemosphere,2020, doi.org/10.1016/j.chemosphere.2020.126289

12) Zhongran Dai, Yusu Sun, Hui Zhang, Dexin Ding, Le Li. Rational synthesis of polyamidoxime/polydopamine decorated graphene oxide composites for efficient uranium(VI) removal from mine radioactive wastewater, Ind. Eng. Chem. Res., 2019, 58: 19280-19291

13) Zhongran Dai, Yusu Sun, Hui Zhang, Dexin Ding, Le Li. Highly Efficient Removal of Uranium(VI) from Wastewater by olyamidoxime/Polyethyleneimine Magnetic Graphene Oxide, J. Chem. Eng. Data, 2019, 64: 5797-5805.

14) Jinhua Xue,Ling Liu,Yongsheng Wang*,Jiaqian Li,Mei Li,Yuening Qu,Le Li*.Assay of 1-hydroxypyrene via aggregation-induced quenching of the fluorescence of protamine-modified gold nanoclusters and 9-hydroxyphenanthrene-based sensitization[J].Microchimica Acta, 2019, doi.org/10.1007/s00604-019-3810-1

15) Wei Lu,Shuangyang Tang,Le Li*,Bin Cheng, Chen Cao,Ling Liu,Tuo Chen. Adsorption and Recovery of Amidoxime Modified nano-Fe3O4 -Aspergillus niger for U(VI) from Low Concentration Uranium Solution[J].Nanoscience and Nanotechnology Letters,2019,11(3):337-345.  

16) Hongyi Xiang,Wei Lu,Le Li*.Synthesis and characterization of phosphorylated Aspergillus niger for effective adsorption of Uranium(VI)[J].Journal of Radioanalytical and Nuclear Chemistry,2019,323(1):379-386.

17) Le Li,Qi Liao,Chen Cao,Shuangyang Tang,Dexin Ding,Yali Yuan,Bin Cheng, Dandan Ma,Wei Lu,Shaoyan Hou. 4-Sulfonylcalix[6]Arene Modified Fe3O4@Aspergillus Niger Biosorbents for Effective Removal of Uranium(VI) from Aqueous Solutions[J].Journal of Nanoscience and Nanotechnology,2018,19(11):6978-6986.  

18) Le Li,Wei Lu,Dexin Ding,Zhongran Dai,Chen Cao,Ling Liu,Tuo Chen.Adsorption Properties of Pyrene-Functionalized Nano-Fe3O4 Mesoporous Materials for Uranium[J].Journal of Solid State Chemistry,2018,270:666-673.  

19) Le Li,Hu Nan,Zhonagran Dai,Hui Zhang,Dexin Ding,Wei Lu.Efficient and selective removal of uranium(VI) from aqueous solution by ethylenediamine- and amidoxime- decorated Aspergillus niger[J].International Journal of Environmental Science and Technology,2018,16(11):7523-7534.  

20) Le Li,Shuangyang Tang,Bin Cheng,Qi Liao,Wei Lu, Yan Tan,Jing Sun.Synthesis and adsorption characteristics of calix[6]arene derivative modified Aspergillus niger-Fe3O4 bio-nanocomposite for U(VI)[J].Journal of Radioanalytical and Nuclear Chemistry,2018,316(1):331-339.  

21) Wei Lu,Le Li* ,Dexin Ding, Shuangyang Tang,Chen Cao,Ling Liu,Tuo Chen.Selective Adsorption of Uranium (VI) by Calix[6]arene-Modified Magnetic Graphene Oxide[J].Journal of Nanoscience and Nanotechnology,2018,18(12):8160–8168.

22) Qi Liao,Le Li*,Yali Yuan,Bin Cheng,Wei Lu,Shaoyan Hou.Preparation of 4-sulfonylcalix[6]arene modified Fe3O4 as adsorbent for adsorption of U(VI) from aqueous solution[J].Journal of Radioanalytical and Nuclear Chemistry,2018,315(2):251-261.  

23) Yan Tan,Le Li,Hui Zhang,Dexin Ding,Zhongran Dai,Jinhua Xue,Jinquan Liu,Nan Hu,Yongdong Wang.Adsorption and recovery of U(VI) from actual acid radioactive wastewater with low uranium concentration using thioacetamide modified activated carbon from liquorice residue[J].Journal of Radioanalytical and Nuclear Chemistry,2018,317(2):811-824.

24) Zhongran Dai, Hui Zhang, Yang Sui, Dexin Ding, Nan Hu, Le Li. Yongdong Wang, Synthesis and characterization of a novel core–shell magnetic nanocomposite via surface-initiated RAFT polymerization for highly efficient and selective adsorption of uranium(VI), Journal of Radioanalytical and Nuclear Chemistry, 2018, 316: 369-382.

25) Zhongran Dai, Hui Zhang, Yang Sui, Dexin Ding, Le Li. Preparation of polyamidoxime/magnetic graphene oxide composite andits application for efficient extraction of uranium(VI) from aqueous solutions in an ultrasonic field, J. Chem. Eng. Data, 2018, 63: 4215-4225.

26) Hui Zhang,Zhongran Dai,Yang Sui,Nieying Wang,Haiying Fu,Dexin Ding,Nan Hu,Guangyue Li,Yongdong Wang,Le Li.Scavenging of U(VI) from Impregnated Water at Uranium Tailings Repository by Tripolyphosphate Intercalated LDH[J].Industrial and Engineering Chemistry Research,2018,57(50):17318-17327.

27) Yi Wen,Yali Yuan,Le Li,Dandan Ma,Qi Liao,Shaoyan Hou.Ultrasensitive DNAzyme based amperometric determination of uranyl ion using mesoporous silica nanoparticles loaded with Methylene Blue[J].Microchimica Acta,2017,184(10):3909-3917.

28) Hui Zhang,Jinhua Xue,Nan Hu,Jing Sun,Dexin Ding,Yongdong Wang,Le Li.Selective removal of U(VI) from low concentration wastewater by functionalized HKUST-1@H3PW12O40[J].Journal of Radioanalytical and Nuclear Chemistry,2016,308(3):865-875.  

29) Le Li,Nan Hu,Dexin Ding,Xin Xin,Yongdong Wang,Jinhua Xue,Hui Zhang,Yan Tan.Adsorption and recovery of U(VI) from low concentration uranium solution by amidoxime modified Aspergillus niger[J].RSC ADVANCES,2015,5(81):65827-65839.

30) Yongdong Wang,Guangyue Li,Dexin Ding,Zhenyuan Zhang,Jie Chen,Nan Hu,Le Li.Column leaching of uranium ore with fungal metabolic products and uranium recovery by ion exchange[J].Journal of Radioanalytical and Nuclear Chemistry,2015,304(3):1139-1144.

31) Le Li,Dexin Ding,Nan Hu,Pingkun Fu,Xin Xin,Yongdong Wang.Adsorption of U(VI) ions from low concentration uranium solution by thermally activated sodium feldspar[J].Journal of Radioanalytical and Nuclear Chemistry,2014,299(1):681-690.  

32) Shuangyang Tang,Le Li,Yaolin Li,Anyuan Liu,Minjun Yu,Yanpin Wan.Distribution and location of Daxx in cervical epithelial cells with high risk human papillomavirus positive[J].Diagnostic Pathology,2014,9:1-9.  

33) Shuangyang Tang,Le Li,Liu Yan,Anyuan Liu,Minjun Yu,Yan Zhang,Yanping Wan. Interaction of Daxx and Human Papillomavirus Type 16 E2 Protein[J].Molekuliarnaia Biologiia,2014,48(4):682-686.

34) Dexin Ding,Xin Xin,Le Li,Nan Hu,Guangyue Li,Yongdong Wang,Pingkun Fu.Removal and Recovery of U(VI) from Low Concentration Radioactive Wastewater by Ethylenediamine-Modified Biomass of Aspergillus niger[J].Water Air and Soil Pollution,2014, 225(12):2206-2221.  

35) Dexin Ding,Pingkun Fu,Le Li,Xin Xin,Nan Hu,Guangyue Li.U(VI) ion adsorption thermodynamics and kinetics from aqueous solution onto raw sodium feldspar and acid-activated sodium feldspar[J].Journal of Radioanalytical and Nuclear Chemistry,2014,299(3):1903-1909.

36) Yangyang Gao,Yali Yuan,Dandan Ma,Le Li,Yuhui Li,Wenhui Xu,Wei Tao.Removal of aqueous uranyl ions by magnetic functionalized carboxymethylcellulose and adsorption property investigation[J].Journal of Nuclear Materials,2014,453(1-3):82-90.  

37) Nan Hu,Dexin Ding,Guangyue Li,Jifang Zheng,Le Li,Weichao Zhao,Yongdong Wang.Vegetation composition and Ra-226 uptake by native plant species at a uranium mill tailings impoundment in South China[J].Journal of Environmental Radioactivity,2014,129:100-106.  

38) Qiumei Qian,Yongsheng Wang,Bin Zhou,Jinhua Xue,Le Li,Yongsong Wang,Jiacheng Wang,Jicheng Yin,Shandu Liu,Hui Zhao,Hui Liu.Fluorescence quenching determination of metallothioneins using 8-hydroxyquinoline-5-sulphonic acid–Cd(II) chelate[J].Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy,2014,118:992-998.  

39) Shuangyang Tang,Zhihua Liu,Le Li,Hengling Cai,Yanping Wan.Awareness and Knowledge About Human Papillomavirus Among High School Students in China[J].Journal of Reproductive Medicine,2014,59(1-2):44-50.

40) Le Li,Fen Huang,Yali Yuan,Jianbang Hu,Qiong Tang,Shuangyang Tang.Preparation and sorption performance of magnetic 18-crown-6/Fe3O4 nanocomposite for Uranium(VI) in solution[J].Journal of Radioanalytical and Nuclear Chemistry,2013,298(1):227-235.  

 



 

3主要研教改项目

1

湖南省教改研究项目:大预防观背景下应急型预防医学人才培养体系研究与实践。2014-2017年,主持

2

湖南省学位与研究生教育教学改革研究课题:基于一中心两基本点三注重的高素质应急型公共卫生研究生培养体系研究与实践,2018-2020,主持

3

南华大学校级教改项目:基于应急能力提升的卓越公共卫生医师培养研究与实践。2012-2014年,主持

4

南华大学校级教改项目,医学生应对突发公共卫生事件应急响应及现场处置能力培养体系研究。2009-2011年,主持

5

南华大学学位与研究生教育教学改革研究课题,基于建构主义的医学硕士研究生学位课程设置探讨。2009-2011年,主持

6

南华大学船山学院教改重点项目,全方位提升省级实验教学示范中心辐射功能,强化独立学院预防医学专业学生应急能力培养。2012-2014年,主持

 

4主要教研教改论文

1) 

李乐,唐双阳,龙鼎新,杨慧仙,于军晖.健康中国背景下地方高校高素质公共卫生与预防医学研究生培养模式与实践[J].医学教育研究与实践,2019,27(6):950-952,993.

2) 

李乐,龙鼎新,何淑雅,唐双阳,廖力,谢红卫,李良,让蔚清.基于应急能力提升的卓越公共卫生人才培养模式初探[J].中国高等医学教育,2012,(9):12-13.   

3) 

李乐.大预防观背景下医学生应急能力培养体系的构建[J].中国高等医学教育,2012,(1):38-39.  

4) 

李乐.以建构主义为核心理念强化医学硕士生应急能力[J].基础医学教育,2012,14(8):638-640.

5) 

李乐,龙鼎新,唐双阳,何淑雅,贺性鹏,黄波,让蔚清.新形势下应急型预防医学人才培养举措初探[J].基础医学教育.2013,15(8):765-767.   

6) 

李乐,让蔚清,龙鼎新,唐双阳,黄波,唐艳,肖方竹.全球化视野下的应急型预防医学人才培养探讨[J].西北医学教育,2015,23(3):439-440.   

7) 

李乐,让蔚清,唐双阳,龙鼎新,龙理良,唐艳,肖方竹.对医学生突发公共卫生事件应急响应能力培养体系的研究[J].西北医学教育,2009,(5):872-873.

 

5)专著和教材

1)

主编《功能性吸附剂构建及放射性污染防控》,中国原子能出版社,2019年。

副主编《放射医学实验方法与技能》,中国原子能出版社,2014年。

参编《预防医学实验方法与实践技能》,人民卫生出版社,2012

2

3

 

三、人才培养

        培养指导研究生情况:已毕业11硕士(周智慧、杨珍成彬卢炜廖琪曹晨、杨冬凤、刘玲、朱冰玉、孙琳、陈磊)。

主讲本科课程:生物材料检验、医学放射生物学、放射卫生学、放射毒理学

主讲研究生课程:放射生物学放射卫生前沿进展现代卫生化学。

 

四、研究生招生方向

博士生:基础医学(放射生物学)

硕士生:公共卫生与预防医学(卫生检验学)、公共卫生(卫生检验与检疫)

 

、联系方式:

话:0734-8282207(办)

E-mailusclile@126.com

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