（一）科研项目

1

湖南省教育厅，一般项目，2324JY189，靶向铁死亡探究苏木酮A缓解炎症性肠病的作用及分子机制，2024-01至2026-12，1万元，主持。

2

湖南省科技厅，湖南省重点研发计划，2020NK2032，畜禽主要非传染性群发病防控关键技术研究，2021-01至2022-12，50万元，参与。

3

湖南省科技厅，湖南省自然科学基金面上项目，2020JJ4368，基于ROS-NLRP3炎性通路研究桦木酸缓解断奶仔猪肠道炎症的作用机制，2020-01至2022-12，5万元，参与。

4

湖南省发展与改革委员会，创新研发项目，202114，基于Nrf2/MAPK信号通路研究桦木酸缓解玉米赤霉烯酮致睾丸氧化损伤的保护机制，2021-03至2022-12，10万元，参与。

5

湖南省发展与改革委员会，创新研发项目，201937，基于NF-κB/MAPK/ Nrf2-HO-1信号通路研究桦木酸缓解T-2毒素致肠黏膜氧化损伤的保护机制，2019-09至2021-08，10万元，参与。

2）

Ma Y#, Xiang S#, Jiang W, Kong L, Tan Z, Liang Z, Yuan Z, Yi J*, Zhu L*. Gamma-oryzanol protects human liver cell (L02) from hydrogen peroxide-induced oxidative damage through regulation of the MAPK/Nrf2 signaling pathways. Journal of Food Biochemistry, 2022: e14118.（通讯作者）

3）

Zhu L#, Luo C#, Ma C, Kong L, Huang Y, Yang W, Huang C, Jiang W*, Yi J*. Inhibition of the NF-κB pathway and ERK-mediated mitochondrial apoptotic pathway takes part in the mitigative effect of betulinic acid on inflammation and oxidative stress in cyclophosphamide-triggered renal damage of mice. Ecotoxicology and Environmental Safety, 2022, 246: 114150.

4）

Zhu L#, Yi X#, Ma C, Luo C, Kong L, Lin X, Gao Y, Yuan Z, Wen L, Li R, Wu J*, Yi J*. Betulinic acid attenuates oxidative stress in the thymus induced by acute exposure to T-2 toxin via regulation of the MAPK/Nrf2 signaling pathway. Toxins, 2020, 12(9): 540.

5）

Zhu L#, Xiang S#, Ou Z, Ma C, Yi X, Huang L, Ma Y, Liang Z, Yuan Z, Wen L, Li R, Wu J, Tan Z*, Yi J*. Gamma-oryzanol prevents ethanol-induced liver injury by ameliorating oxidative stress and modulating apoptosis-related protein expression in mice. Journal of Functional Foods, 2019, 62, 103532.

6）

Zhu L, Yi X, Zhao J, Yuan Z, Wen L, Pozniak B, Obminska-Mrukowicz B, Tian Y, Tan Z, Wu J*, Yi J*. Betulinic acid attenuates dexamethasone-induced oxidative damage through the JNK-P38 MAPK signaling pathway in mice. Biomedicine & Pharmacotherapy, 2018, 103: 499-508.

7）

Lin X#, Zhu L#, Gao X, Kong L, Huang Y, Zhao H, Chen Y, Wen L, Li R, Wu J, Yuan Z*, Yi J*. Ameliorative effect of betulinic acid against zearalenone exposure triggers testicular dysfunction and oxidative stress in mice via p38/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation. Ecotoxicology and Environmental Safety, 2022, 238: 113561.（共同一作）

8）

Kong L#, Zhu L#, Yi X, Huang Y, Zhao H, Chen Y, Yuan Z, Wen L, Wu J*, Yi J*. Betulinic acid alleviates spleen oxidative damage induced by acute intraperitoneal exposure to T-2 toxin by activating Nrf2 and inhibiting MAPK signaling pathways. Antioxidants, 2021, 10(2): 158.（共同一作）

9）

Ou Z#, Zhu L#, Huang C, Ma C, Kong L, Lin X, Gao X, Huang L, Wen L, Liang Z, Yuan Z, Wu J*, Yi J*. Betulinic acid attenuates cyclophosphamide-induced intestinal mucosa injury by inhibiting the NF-κB/MAPK signalling pathways and activating the Nrf2 signalling pathway. Ecotoxicology and Environmental Safety, 2021, 225: 112746.（共同一作）

10）

Huang L#, Zhu L#, Ou Z, Ma C, Kong L, Huang Y, Chen Y, Zhao H, Wen L, Wu J, Yuan Z*, Yi J*. Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice. International Immunopharmacology, 2021, 101: 108210.（共同一作）

11）

Kong L#, Gao X#, Zhu L, Lin X, Huang Y, Huang C, Yang W, Chen Y, Zhao H, Wu J, Yuan Z*, Yi J*. Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice. Food Science and Human Wellness, 2024, 13(3): 1292-1302.

12）

Ou Z#, Zhao J#, Zhu L, Huang L, Ma Y, Ma C, Luo C, Zhu Z, Yuan Z, Wu J, Li R*, Yi J*. Anti-inflammatory effect and potential mechanism of betulinic acid on λ-carrageenan-induced paw edema in mice. Biomedicine & Pharmacotherapy, 2019, 118: 109347.

13）

Huang L#, Jiang W#, Zhu L, Ma C, Ou Z, Luo C, Wu J, Wen L, Tan Z*, Yi J*. γ-Oryzanol suppresses cell apoptosis by inhibiting reactive oxygen species-mediated mitochondrial signaling pathway in H₂O₂-stimulated L02 cells. Biomedicine & Pharmacotherapy, 2020, 121: 109554.

14）

Luo C#, Huang C#, Zhu L, Kong L, Yuan Z, Wen L, Li R, Wu J*, Yi J*. Betulinic acid ameliorates the T-2 toxin-triggered intestinal impairment in mice by inhibiting inflammation and mucosal barrier dysfunction through the NF-κB signaling pathway. Toxins. 2020, 12(12): 794.

15）

Wang X#, Yuan Z#, Zhu L, Yi X, Ou Z, Li R, Tan Z, Pozniak B, Obminska-Mrukowicz B, Wu J*, Yi J*. Protective effects of betulinic acid on intestinal mucosal injury induced by cyclophosphamide in mice. Pharmacological Reports, 2019, 71(5): 929-939.