南华大学公共卫生学院研究生导师简介
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姓 名: |
朱利娟 |
出生年月: |
1991年4月 |
学 位: |
博士研究生 |
职称/职务: |
讲师 |
籍贯: |
湖南省娄底市 |
研究方向: |
营养与健康 |
一、基本情况
南华大学公共卫生学院营养与食品卫生学教研室教师,博士,讲师,硕士生导师。主要从事营养代谢相关的研究。主持湖南省教育厅一般项目1项,参加湖南省重点研发计划、湖南省自然科学基金、湖南省发展与改革委员会创新平台建设项目等多项研究课题。目前已发表学术论文共计30余篇,其中以第一作者或通讯作者在《Food & Function》、《Ecotoxicology and Environmental Safety》、《Journal of Functional Foods》、《Antioxidants》、《Biomedicine & Pharmacotherapy》、《Toxins》、《International Immunopharmacology》、《Journal of Food Biochemistry》等杂志上发表SCI论文10篇,以第一作者或通讯作者发表中文核心期刊6篇。
(一)教育背景
2009.9-2013.6 湖南农业大学,动物医学,学士
2014.9-2017.6 湖南农业大学,临床兽医学,硕士,导师:易金娥教授
2019.9 -2023.6 湖南农业大学,兽医学,博士,导师:易金娥教授
(二)工作经历
2017.7-2019.8 长沙绿叶生物科技有限公司,研发专员
2023.7-今 南华大学公共卫生学院营养与食品卫生学教研室,预防医学教学与科研工作,讲师
二、教学与科研情况 |
(一)科研项目 |
1 |
湖南省教育厅,一般项目,2324JY189,靶向铁死亡探究苏木酮A缓解炎症性肠病的作用及分子机制,2024-01至2026-12,1万元,主持。 |
2 |
湖南省科技厅,湖南省重点研发计划,2020NK2032,畜禽主要非传染性群发病防控关键技术研究,2021-01至2022-12,50万元,参与。 |
3 |
湖南省科技厅,湖南省自然科学基金面上项目,2020JJ4368,基于ROS-NLRP3炎性通路研究桦木酸缓解断奶仔猪肠道炎症的作用机制,2020-01至2022-12,5万元,参与。 |
4 |
湖南省发展与改革委员会,创新研发项目,202114,基于Nrf2/MAPK信号通路研究桦木酸缓解玉米赤霉烯酮致睾丸氧化损伤的保护机制,2021-03至2022-12,10万元,参与。 |
5 |
湖南省发展与改革委员会,创新研发项目,201937,基于NF-κB/MAPK/ Nrf2-HO-1信号通路研究桦木酸缓解T-2毒素致肠黏膜氧化损伤的保护机制,2019-09至2021-08,10万元,参与。
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(二)代表性科研和教改论文
1.代表性科研论文
1) |
He E#, Ma Y#, Kong L, Huang Y, Huang C, Yang W, Yi J*, Zhu L*. Suppression of endoplasmic reticulum stress-associated pathways and hepatocyte apoptosis participates in the attenuation of betulinic acid on alcohol-provoked liver injury in mice. Food & Function, 2022, 13(22): 11489-11502.(通讯作者) |
2) |
Ma Y#, Xiang S#, Jiang W, Kong L, Tan Z, Liang Z, Yuan Z, Yi J*, Zhu L*. Gamma-oryzanol protects human liver cell (L02) from hydrogen peroxide-induced oxidative damage through regulation of the MAPK/Nrf2 signaling pathways. Journal of Food Biochemistry, 2022: e14118.(通讯作者) |
3) |
Zhu L#, Luo C#, Ma C, Kong L, Huang Y, Yang W, Huang C, Jiang W*, Yi J*. Inhibition of the NF-κB pathway and ERK-mediated mitochondrial apoptotic pathway takes part in the mitigative effect of betulinic acid on inflammation and oxidative stress in cyclophosphamide-triggered renal damage of mice. Ecotoxicology and Environmental Safety, 2022, 246: 114150. |
4) |
Zhu L#, Yi X#, Ma C, Luo C, Kong L, Lin X, Gao Y, Yuan Z, Wen L, Li R, Wu J*, Yi J*. Betulinic acid attenuates oxidative stress in the thymus induced by acute exposure to T-2 toxin via regulation of the MAPK/Nrf2 signaling pathway. Toxins, 2020, 12(9): 540. |
5) |
Zhu L#, Xiang S#, Ou Z, Ma C, Yi X, Huang L, Ma Y, Liang Z, Yuan Z, Wen L, Li R, Wu J, Tan Z*, Yi J*. Gamma-oryzanol prevents ethanol-induced liver injury by ameliorating oxidative stress and modulating apoptosis-related protein expression in mice. Journal of Functional Foods, 2019, 62, 103532. |
6) |
Zhu L, Yi X, Zhao J, Yuan Z, Wen L, Pozniak B, Obminska-Mrukowicz B, Tian Y, Tan Z, Wu J*, Yi J*. Betulinic acid attenuates dexamethasone-induced oxidative damage through the JNK-P38 MAPK signaling pathway in mice. Biomedicine & Pharmacotherapy, 2018, 103: 499-508. |
7) |
Lin X#, Zhu L#, Gao X, Kong L, Huang Y, Zhao H, Chen Y, Wen L, Li R, Wu J, Yuan Z*, Yi J*. Ameliorative effect of betulinic acid against zearalenone exposure triggers testicular dysfunction and oxidative stress in mice via p38/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation. Ecotoxicology and Environmental Safety, 2022, 238: 113561.(共同一作) |
8) |
Kong L#, Zhu L#, Yi X, Huang Y, Zhao H, Chen Y, Yuan Z, Wen L, Wu J*, Yi J*. Betulinic acid alleviates spleen oxidative damage induced by acute intraperitoneal exposure to T-2 toxin by activating Nrf2 and inhibiting MAPK signaling pathways. Antioxidants, 2021, 10(2): 158.(共同一作) |
9) |
Ou Z#, Zhu L#, Huang C, Ma C, Kong L, Lin X, Gao X, Huang L, Wen L, Liang Z, Yuan Z, Wu J*, Yi J*. Betulinic acid attenuates cyclophosphamide-induced intestinal mucosa injury by inhibiting the NF-κB/MAPK signalling pathways and activating the Nrf2 signalling pathway. Ecotoxicology and Environmental Safety, 2021, 225: 112746.(共同一作) |
10) |
Huang L#, Zhu L#, Ou Z, Ma C, Kong L, Huang Y, Chen Y, Zhao H, Wen L, Wu J, Yuan Z*, Yi J*. Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice. International Immunopharmacology, 2021, 101: 108210.(共同一作) |
11) |
Kong L#, Gao X#, Zhu L, Lin X, Huang Y, Huang C, Yang W, Chen Y, Zhao H, Wu J, Yuan Z*, Yi J*. Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice. Food Science and Human Wellness, 2024, 13(3): 1292-1302. |
12)
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Ou Z#, Zhao J#, Zhu L, Huang L, Ma Y, Ma C, Luo C, Zhu Z, Yuan Z, Wu J, Li R*, Yi J*. Anti-inflammatory effect and potential mechanism of betulinic acid on λ-carrageenan-induced paw edema in mice. Biomedicine & Pharmacotherapy, 2019, 118: 109347. |
13) |
Huang L#, Jiang W#, Zhu L, Ma C, Ou Z, Luo C, Wu J, Wen L, Tan Z*, Yi J*. γ-Oryzanol suppresses cell apoptosis by inhibiting reactive oxygen species-mediated mitochondrial signaling pathway in H2O2-stimulated L02 cells. Biomedicine & Pharmacotherapy, 2020, 121: 109554. |
14) |
Luo C#, Huang C#, Zhu L, Kong L, Yuan Z, Wen L, Li R, Wu J*, Yi J*. Betulinic acid ameliorates the T-2 toxin-triggered intestinal impairment in mice by inhibiting inflammation and mucosal barrier dysfunction through the NF-κB signaling pathway. Toxins. 2020, 12(12): 794. |
15) |
Wang X#, Yuan Z#, Zhu L, Yi X, Ou Z, Li R, Tan Z, Pozniak B, Obminska-Mrukowicz B, Wu J*, Yi J*. Protective effects of betulinic acid on intestinal mucosal injury induced by cyclophosphamide in mice. Pharmacological Reports, 2019, 71(5): 929-939. |
三、联系方式
电话:18874205749
E-mail:zhulijuan@usc.edu.cn
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